LOPINAVIR….Indicated in combination with other antiretroviral agents for the treatment of HIV-infection.

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New Drug Approvals





(2S,3S,5S)-2-(-2,6- dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2-(1-tetrahydropyrimid-2-onyl)-3- methylbutanoyl)amino-1 ,6-diphenylhexane


Abbott Laboratories
 CAS 192725-17-0
AHFS/Drugs.com International Drug Names
MedlinePlus a602015
Pregnancy cat. C (US)
Legal status POM(UK)-only(US)




ABT-378, Aluviran, Koletra, ABT 378, 1mui, 2rkf, 2rkg, A 157378.0, RS-346
Molecular Formula: C37H48N4O5   Molecular Weight: 628.80082


Inhibitors of human immunodeficiency virus (HIV) protease have been approved for use in the treatment of HIV infection for several years. A particularly effective and recently approved HIV protease inhibitor is (2S,3S,5S)-2-(-2,6- dimethylphenoxyacetyl)-amino-3-hydroxy-5-(2-(1-tetrahydropyrimid-2-onyl)-3- methylbutanoyl)amino-1 ,6-diphenylhexane (also known as lopinavir).

Figure imgf000004_0001


Lopinavir is known to have utility for the inhibition of HIV protease and the inhibition of HIV infection. Lopinavir is particularly effective for the inhibition of HIV protease and for the inhibition of HIV…

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