Female viagra……….UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder

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New Drug Approvals

UK-414,495 structure.pngUK-414,495

Molecular Formula: C16H25N3O3S

Molecular Weight: 339.453

UK 414495

CAS  388630-36-2

OF

(-​)​-​(2R)​-​2-​[[1-​[[(5-​Ethyl-​1,​3,​4-​thiadiazol-​2-​yl)​amino]​carbonyl]​cyclopentyl]​methyl]​pentanoic acid;

AND

Cyclopentanepropanoi​c acid, 1-​[[(5-​ethyl-​1,​3,​4-​thiadiazol-​2-​yl)​amino]​carbonyl]​-​α-​propyl-​, (αR)​-

((R)-2-({1-[(5-ethyl-1,3,4-thiadiazol-2-yl) carbamoyl]cyclopentyl}methyl) valeric acid)

(2R)-2-[(1-{[(5-Ethyl-1,3,4-thiadiazol-2-yl)amino]carbonyl}cyclopentyl) methyl]pentanoic acid

…………………………………………………

Cas 337962-93-3  RACEMIC…………2-​[[1-​[[(5-​Ethyl-​1,​3,​4-​thiadiazol-​2-​yl)​amino]​carbonyl]​cyclopentyl]​methyl]​pentanoic acid  

…………………………………………………………………..

ITS ENANTIOMER

(+)​-​(2S)​-​2-​[[1-​[[(5-​Ethyl-​1,​3,​4-​thiadiazol-​2-​yl)​amino]​carbonyl]​cyclopentyl]​methyl]​pentanoic acid……………337962-74-0

Pfizer Inc.

CAS SUMMARY

 Cas number 388630-36-2
337962-74-0 (enantiomer)
337962-93-3 (racemate)
388630-59-9 (sodium salt)

Figure US20020052370A1-20020502-C00058desired

UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder.[1] UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation.[2][3][4]

Female sexual arousal consists of a number of physiological responses resulting from increased…

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